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Synthetic methodology

Arene additions

Nature Chemistry volume 15, pages 745–746 (2023)Cite this article

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Dipolar cycloadditions are excellent processes for generating heterocyclic systems from simple starting materials, but arenes as dipolarophiles have not been extensively explored. Now, the intramolecular dipolar cycloaddition of aromatic rings has been achieved using in situ generated diazoalkenes to produce bicyclic or tricyclic heterocycles.

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Fig. 1: Mechanistic analysis for the conversion of sulfonyl azides and lithium acetylides to Sultams, SulfoIns and NH-triazoles.

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  1. Twitter: @MitchCroatt

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  1. Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA

    Abraham Ustoyev & Mitchell P. Croatt

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  1. Abraham Ustoyev
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  2. Mitchell P. Croatt
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Correspondence to Mitchell P. Croatt.

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Ustoyev, A., Croatt, M.P. Arene additions. Nat. Chem. 15, 745–746 (2023). https://doi.org/10.1038/s41557-023-01190-5

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