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Looking into luciferin

Organisms that glow are perhaps eerie. Vadim Viviani ponders on the luciferin–luciferase systems responsible for their intriguing bioluminescence.

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  1. Dubois, R. Compt. Rend. Soc. Biol. 37, 559–562 (1885).

    Google Scholar 

  2. Harvey, E. N. Bioluminescence (Academic Press, 1952).

  3. Shimomura, O. Bioluminescence: Chemical Principles and Methods (World Scientific, 2006).

  4. White, E. H., McCapra, F., Field, G. & McElroy, W. D. J. Am. Chem. Soc. 83, 2402–2403 (1961).

    Article  CAS  Google Scholar 

  5. Viviani, V. R. in CRC Handbook of Organic Photochemistry and Photobiology 3rd edn (eds Griesbeck, A. et al) Ch. 54 (Taylor & Francis Group, 2012).

  6. Ando, Y. et al. Nat. Photon. 2, 44–47 (2008).

    Article  CAS  Google Scholar 

  7. Roda, A., Guardigli, M., Michelini, E. & Mirasoli, M. Trends Anal. Chem. 28, 307–322 (2009).

    Article  CAS  Google Scholar 

  8. Wilson, T. & Hastings J. W. Bioluminescence: Living Lights, Lights for Living (Harvard Univ. Press, 2013).

  9. Kotlobay, A. A. et al. Proc. Natl Acad. Sci. USA 115, 12728–12732 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Branchini, B. R., Hayward, M. M., Bamford, S., Brennan, P. M. & Lajiness, E. J. Photochem. Photobiol. 49, 689–695 (1989).

    Article  CAS  PubMed  Google Scholar 

  11. Viviani, V. R. Int. J. Mol. Sci. 22, 303 (2021).

    Article  CAS  Google Scholar 

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Correspondence to Vadim R. Viviani.

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The author declares no competing interests.

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Viviani, V.R. Looking into luciferin. Nat. Chem. 15, 742 (2023).

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