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Synthetic methodology

Amino amide assembly

Enantioenriched β-amino acid derivatives are attractive synthetic targets, considering the significance of these motifs in medicinal and material chemistry. Now, using ambiphilic ynamides as two-carbon synthons in a four-component reaction, three classes of β-amino amides with well-defined stereocentres can be accessed.

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Fig. 1: Modular synthesis of amino amides.


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Correspondence to Sunliang Cui.

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Cui, S., Zeng, L. Amino amide assembly. Nat. Chem. 15, 597–598 (2023).

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