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Nanomachines built from multiple components can have functional advantages

Nanomachines are central to life and are becoming an important part of self-regulated nanotechnologies. Inspired by natural self-assembled nanosystems, it has been shown that artificial nanosystems can evolve and adopt regulatory functions upon fragmentation of their structures into multiple components that reassemble to form the same nanostructure.

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Fig. 1: Functional advantages of building nanosystems from multiple molecular components.


  1. Marsh, J. A. & Teichmann, A. A. Structure, dynamics, assembly, and evolution of protein complexes. Annu. Rev. Biochem. 84, 551–575 (2015). A review article that presents the abundance, characterization and role of protein complexes in biological processes.

    Article  CAS  PubMed  Google Scholar 

  2. Harroun, S. G. et al. Programmable DNA switches and their applications. Nanoscale 10, 4607–4641 (2018). A review article that presents the role of DNA-based switches in numerous applications, including biosensing, drug delivery and molecular computing.

    Article  CAS  PubMed  Google Scholar 

  3. Manzari, M. T. et al. Targeted drug delivery strategies for precision medicines. Nat. Rev. Mater. 6, 351–370 (2021). A review article that presents strategies for targeted drug delivery and their future challenges.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Michnick, S. W., Ear, P. H., Manderson, E. N., Remy, I. & Stefan, E. Universal strategies in research and drug discovery based on protein-fragment complementation assays. Nat. Rev. Drug Discov. 6, 569–582 (2007). A review article about protein-fragment complementation assays, showing that proteins can readily sustain fragmentation into split protein systems.

    Article  CAS  PubMed  Google Scholar 

  5. Pasek, S., Risler, J.-L. & Brézellec, P. Gene fusion/fission is a major contributor to evolution of multi-domain bacterial proteins. Bioinformatics 22, 1418–1423 (2006). An article that reports the mechanism of gene fission.

    Article  CAS  PubMed  Google Scholar 

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This is a summary of: Lauzon, D. & Vallée-Bélisle, A. Functional advantages of building nanosystems using multiple molecular components. Nat. Chem. (2023).

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Nanomachines built from multiple components can have functional advantages. Nat. Chem. 15, 454–455 (2023).

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