Nanomachines are central to life and are becoming an important part of self-regulated nanotechnologies. Inspired by natural self-assembled nanosystems, it has been shown that artificial nanosystems can evolve and adopt regulatory functions upon fragmentation of their structures into multiple components that reassemble to form the same nanostructure.
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References
Marsh, J. A. & Teichmann, A. A. Structure, dynamics, assembly, and evolution of protein complexes. Annu. Rev. Biochem. 84, 551–575 (2015). A review article that presents the abundance, characterization and role of protein complexes in biological processes.
Harroun, S. G. et al. Programmable DNA switches and their applications. Nanoscale 10, 4607–4641 (2018). A review article that presents the role of DNA-based switches in numerous applications, including biosensing, drug delivery and molecular computing.
Manzari, M. T. et al. Targeted drug delivery strategies for precision medicines. Nat. Rev. Mater. 6, 351–370 (2021). A review article that presents strategies for targeted drug delivery and their future challenges.
Michnick, S. W., Ear, P. H., Manderson, E. N., Remy, I. & Stefan, E. Universal strategies in research and drug discovery based on protein-fragment complementation assays. Nat. Rev. Drug Discov. 6, 569–582 (2007). A review article about protein-fragment complementation assays, showing that proteins can readily sustain fragmentation into split protein systems.
Pasek, S., Risler, J.-L. & Brézellec, P. Gene fusion/fission is a major contributor to evolution of multi-domain bacterial proteins. Bioinformatics 22, 1418–1423 (2006). An article that reports the mechanism of gene fission.
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This is a summary of: Lauzon, D. & Vallée-Bélisle, A. Functional advantages of building nanosystems using multiple molecular components. Nat. Chem. https://doi.org/10.1038/s41557-022-01127-4 (2023).
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Nanomachines built from multiple components can have functional advantages. Nat. Chem. 15, 454–455 (2023). https://doi.org/10.1038/s41557-023-01167-4
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DOI: https://doi.org/10.1038/s41557-023-01167-4
