Nanomachines are central to life and are becoming an important part of self-regulated nanotechnologies. Inspired by natural self-assembled nanosystems, it has been shown that artificial nanosystems can evolve and adopt regulatory functions upon fragmentation of their structures into multiple components that reassemble to form the same nanostructure.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Marsh, J. A. & Teichmann, A. A. Structure, dynamics, assembly, and evolution of protein complexes. Annu. Rev. Biochem. 84, 551–575 (2015). A review article that presents the abundance, characterization and role of protein complexes in biological processes.
Harroun, S. G. et al. Programmable DNA switches and their applications. Nanoscale 10, 4607–4641 (2018). A review article that presents the role of DNA-based switches in numerous applications, including biosensing, drug delivery and molecular computing.
Manzari, M. T. et al. Targeted drug delivery strategies for precision medicines. Nat. Rev. Mater. 6, 351–370 (2021). A review article that presents strategies for targeted drug delivery and their future challenges.
Michnick, S. W., Ear, P. H., Manderson, E. N., Remy, I. & Stefan, E. Universal strategies in research and drug discovery based on protein-fragment complementation assays. Nat. Rev. Drug Discov. 6, 569–582 (2007). A review article about protein-fragment complementation assays, showing that proteins can readily sustain fragmentation into split protein systems.
Pasek, S., Risler, J.-L. & Brézellec, P. Gene fusion/fission is a major contributor to evolution of multi-domain bacterial proteins. Bioinformatics 22, 1418–1423 (2006). An article that reports the mechanism of gene fission.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Lauzon, D. & Vallée-Bélisle, A. Functional advantages of building nanosystems using multiple molecular components. Nat. Chem. https://doi.org/10.1038/s41557-022-01127-4 (2023).
Rights and permissions
About this article
Cite this article
Nanomachines built from multiple components can have functional advantages. Nat. Chem. 15, 454–455 (2023). https://doi.org/10.1038/s41557-023-01167-4