Post-translational modification of proteins is widely used for studying biological processes; however, competing reactions can provide numerous challenges. Now, a visible-light photocatalytic diselenide contraction enables the highly chemoselective functionalization of selenopeptides and proteins under mild conditions.
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Fitzpatrick, N.A., Musacchio, P.Z. Shining light on diselenide bonds. Nat. Chem. 15, 163–164 (2023). https://doi.org/10.1038/s41557-023-01134-z