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Bioconjugates

Shining light on diselenide bonds

Nature Chemistry volume 15, pages 163–164 (2023)Cite this article

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Post-translational modification of proteins is widely used for studying biological processes; however, competing reactions can provide numerous challenges. Now, a visible-light photocatalytic diselenide contraction enables the highly chemoselective functionalization of selenopeptides and proteins under mild conditions.

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Fig. 1: Photocatalytic diselenide contraction (PDC).

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  1. Patricia Z. Musacchio

    Present address: Department of Chemistry & Biochemistry, Worcester Polytechnic Institute, Worcester, MA, USA

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  1. Department of Chemistry & Biochemistry, Worcester Polytechnic Institute, Worcester, MA, USA

    Nicholas A. Fitzpatrick

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  1. Nicholas A. Fitzpatrick
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  2. Patricia Z. Musacchio
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Correspondence to Patricia Z. Musacchio.

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Fitzpatrick, N.A., Musacchio, P.Z. Shining light on diselenide bonds. Nat. Chem. 15, 163–164 (2023). https://doi.org/10.1038/s41557-023-01134-z

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