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Chemical biology

Cellular decoding for non-natural peptides

Ribosomes cannot synthesize peptides using hydroxy acids to replace canonical amino acids as no codons encode hydroxy acid building blocks. Now, this challenge has been addressed by rewriting the genetic code, enabling the direct cellular biosynthesis of non-natural depsipeptides containing non-canonical amino acids.

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Fig. 1: Cellular biosynthesis of non-natural peptide and depsipeptide macrocycles.


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Correspondence to Jian Li.

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Li, J. Cellular decoding for non-natural peptides. Nat. Chem. 15, 7–8 (2023).

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