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Radical arenes

Radical-mediated functionalization streamlines access to complex synthetic targets. Now, a sulfonium-based donor–acceptor pair enables photoinduced charge-transfer interactions to access electronically diverse aryl radicals. Reaction with enol ethers or isocyanide provides a metal-free method for arene functionalization.

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Fig. 1: Site-selective arene C–H cyanation and alkylation mediated by radicals.


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Correspondence to David A. Nagib.

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Bednar, T.N., Nagib, D.A. Radical arenes. Nat. Chem. 15, 3–4 (2023).

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