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Isotope labelling

Enriched amino acids

The direct carbon isotope exchange reaction on α-amino acids is highly desirable, as existing labelling methods require several synthetic steps and harsh conditions. Now, an aldehyde-catalysed carboxylate exchange with isotopically labelled *CO2 has enabled the direct formation of 11C, 13C and 14C-labelled α-amino acids.

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Fig. 1: The development of a broadly applicable direct isotope exchange reaction on α-amino acids using isotopically labelled CO2.


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Correspondence to Karoline T. Neumann.

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Neumann, K.T., Skrydstrup, T. Enriched amino acids. Nat. Chem. 14, 1339–1340 (2022).

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