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Pop-up rings to rule reactivity

An alcohol-functionalized cyclophane has been shown to form a bowl-shaped cavity large enough to host tris(bipyridine)ruthenium(ii). The macrocycle captures, and suppresses the activity of, the ruthenium complex in water but, when oxidized to its ketone-bearing counterpart, releases the ruthenium guest.

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Fig. 1: Reactivity of tris(bipyridine)ruthenium(ii) complexes ([(bpy)3Ru]2+) controlled through the chemically induced shape-switching of cyclophane receptors.


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Correspondence to David Van Craen.

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Van Craen, D. Pop-up rings to rule reactivity. Nat. Chem. 14, 971–972 (2022).

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