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AMINATION

Back to basics

Amines with free N–H groups have long posed a tremendous challenge in transition metal-catalysed amination reactions. Now, use of a bidentate phosphorus ligand enables the palladium-catalysed oxidative amination of simple olefins with Lewis basic amines, with no prefunctionalization, forming both alkyl and aryl allylamines.

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Fig. 1: Development of practical oxidative amination of terminal olefins.

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Correspondence to Jennifer M. Schomaker.

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Vine, L.E., Schomaker, J.M. Back to basics. Nat. Chem. 14, 1093–1094 (2022). https://doi.org/10.1038/s41557-022-01029-5

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