Malleicyprols are highly reactive polyketides responsible for virulence in some pathogenic bacteria. Now, the enzyme that constructs the cyclopropanol warhead of malleicyprols has been identified. This enzyme could represent a useful target for developing new antivirulence therapeutics.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Davies, J. & Davies, D. Microbiol. Mol. Biol. Rev. 74, 417–433 (2010).
Dickey, S. W., Cheung, G. Y. C. & Otto, M. Nat. Rev. Drug Discov. 16, 457–471 (2017).
Wiersinga, W. J. et al. Nat. Rev. Dis. Primers 4, 17107 (2018).
Klaus, J. R. et al. J. Bacteriol. 200, e00008–18 (2018).
Trottmann, F. et al. Angew. Chem. Int. Ed. 58, 14129–14133 (2019).
Trottmann, F. et al. Nat. Chem. https://doi.org/10.1038/s41557-022-01005-z (2022).
Patel, K. M. et al. Chemistry 23, 18289–18295 (2017).
Ma, S., Mandalapu, D., Wang, S. & Zhang, Q. Nat. Prod. Rep. 39, 926–945 (2022).
Kelly, W. L. et al. Biochemistry 46, 359–368 (2007).
Xu, Z., Pan, G., Zhou, H. & Shen, B. J. Am. Chem. Soc. 140, 16957–16961 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Abraham, E., Butcher, R.A. Warhead assembly in a lethal pathogen. Nat. Chem. 14, 848–850 (2022). https://doi.org/10.1038/s41557-022-01013-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-022-01013-z
