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Warhead assembly in a lethal pathogen

Malleicyprols are highly reactive polyketides responsible for virulence in some pathogenic bacteria. Now, the enzyme that constructs the cyclopropanol warhead of malleicyprols has been identified. This enzyme could represent a useful target for developing new antivirulence therapeutics.

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Fig. 1: Comparison of cyclopropane-forming enzyme mechanisms.


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Correspondence to Rebecca A. Butcher.

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Abraham, E., Butcher, R.A. Warhead assembly in a lethal pathogen. Nat. Chem. 14, 848–850 (2022).

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