How electric fields generated by enzyme active sites push and pull on substrates is important to their chemistry, but measuring them is difficult. Now, the electric field within an active site has been measured along two directions using a vibrational probe, revealing that the field effect in enzymes is different compared with that in bulk solvents.
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Pennathur, A., Dawlaty, J. Electric field maps in enzymes. Nat. Chem. 14, 845–846 (2022). https://doi.org/10.1038/s41557-022-01010-2
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DOI: https://doi.org/10.1038/s41557-022-01010-2
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