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Radical ring formation

N-heterocycles are valuable motifs in pharmaceuticals and materials, but divergent synthetic strategies are lacking. Now, bifunctional sulfilimines have been shown to form nitrogen-centred radicals under photocatalytic conditions, and subsequent coupling with olefins enables the synthesis of diverse N-heterocycles.

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Fig. 1: Discovery of a bifunctional reagent for N-heterocycle synthesis.


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Correspondence to Wei Li.

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Baskaran, P., Li, W. Radical ring formation. Nat. Chem. 14, 850–852 (2022).

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