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ANTIBODY DRUG CONJUGATES

ortho-Quinone drugs go pro

Antibody-mediated delivery of therapeutics has been primarily limited to agents containing amine, alcohol or thiol functional groups. Now, an approach has been developed to create stable and bio-reversible prodrugs that mask ortho-quinones. Drug release requires both protease activation followed by acid-assisted elimination.

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Fig. 1: ADC assembled with an ortho-quinone anti-cancer chemotherapeutic.

References

  1. Drago, J. Z., Modi, S. & Chandarlapaty, S. Nat. Rev. Clin. Oncol. 18, 327–344 (2021).

    Article  Google Scholar 

  2. Staben, L. R. et al. Nat. Chem. 8, 1112–1119 (2016).

    CAS  Article  Google Scholar 

  3. Kolakowski, R. V. et al. Angew. Chem. Int. Ed. 55, 7948–7951 (2016).

    CAS  Article  Google Scholar 

  4. Dunsmore, L. et al. Nat. Chem. https://doi.org/10.1038/s41557-022-00964-7 (2022).

    Article  PubMed  Google Scholar 

  5. Chuprakov, S. et al. Bioconjug. Chem. 32, 746–754 (2021).

    CAS  Article  Google Scholar 

  6. Gong, Q., Hu, J., Wang, P., Li, X. & Zhang, X. Eur. J. Med. Chem. 210, 112962 (2020).

    Article  Google Scholar 

  7. Ma, X. et al. J. Control. Release 200, 201–211 (2015).

    CAS  Article  Google Scholar 

  8. Lehar, S. M. et al. Nature 527, 323–328 (2015).

    CAS  Article  Google Scholar 

  9. Gadd, A. J. R., Greco, F., Cobb, A. J. A. & Edwards, A. D. Bioconjug. Chem. 26, 1743–1752 (2015).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Thomas Pillow.

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Pillow, T. ortho-Quinone drugs go pro. Nat. Chem. 14, 719–720 (2022). https://doi.org/10.1038/s41557-022-00993-2

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