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ortho-Quinone drugs go pro

Antibody-mediated delivery of therapeutics has been primarily limited to agents containing amine, alcohol or thiol functional groups. Now, an approach has been developed to create stable and bio-reversible prodrugs that mask ortho-quinones. Drug release requires both protease activation followed by acid-assisted elimination.

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Fig. 1: ADC assembled with an ortho-quinone anti-cancer chemotherapeutic.


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Correspondence to Thomas Pillow.

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Pillow, T. ortho-Quinone drugs go pro. Nat. Chem. 14, 719–720 (2022).

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