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On gene silencing by the X10-23 DNAzyme

Matters Arising to this article was published on 18 July 2022

The Original Article was published on 25 March 2021

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Fig. 1: RNase H recruitment activity of KRAS RNA-targeting X10-23 DNAzymes on long RNA substrates.


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This work was supported by the Medical Research Council (P.H., program no. MC_U105178804) and the Wellcome Trust and the Royal Society (Sir Henry Dale Fellowship to A.I.T., 215453/Z/19/Z).

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Both authors conceived and designed experiments, A.I.T. performed experiments and both authors analysed data and co-wrote the manuscript.

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Correspondence to Alexander I. Taylor or Philipp Holliger.

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Taylor, A.I., Holliger, P. On gene silencing by the X10-23 DNAzyme. Nat. Chem. 14, 855–858 (2022).

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