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Chemical fuels for molecular machinery

Nature Chemistry volume 14, pages 728–738 (2022)Cite this article

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Abstract

Chemical reaction networks that transform out-of-equilibrium ‘fuel’ to ‘waste’ are the engines that power the biomolecular machinery of the cell. Inspired by such systems, autonomous artificial molecular machinery is being developed that functions by catalysing the decomposition of chemical fuels, exploiting kinetic asymmetry to harness energy released from the fuel-to-waste reaction to drive non-equilibrium structures and dynamics. Different aspects of chemical fuels profoundly influence their ability to power molecular machines. Here we consider the structure and properties of the fuels that biology has evolved and compare their features with those of the rudimentary synthetic chemical fuels that have so far been used to drive autonomous non-equilibrium molecular-level dynamics. We identify desirable, but context-specific, traits for chemical fuels together with challenges and opportunities for the design and invention of new chemical fuels to power synthetic molecular machinery and other dissipative nanoscale processes.

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Fig. 1: Chemically fuelled molecular dynamics.
Fig. 2: Chemical fuels used to power autonomous biological and synthetic molecular machinery.
Fig. 3: Chemical fuels for dissipative supramolecular assembly and macrocyclization.
Fig. 4: Chemical fuels for non-autonomous and non-directional molecular machinery.
Fig. 5: Molecular machines driven by chemical fuel pulses.
Fig. 6: Transition states for fuel-to-waste reactions mediated by molecular machines.

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Acknowledgements

We thank the Engineering and Physical Sciences Research Council (EPSRC; grant number EP/P027067/1) and the European Research Council (ERC; Advanced Grant number 786630) for funding, and S. Amano and E. Kreidt for useful discussions. D.A.L. is a Royal Society Research Professor.

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  1. These authors contributed equally: Stefan Borsley, Benjamin M. W. Roberts.

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  1. Department of Chemistry, University of Manchester, Manchester, UK

    Stefan Borsley, David A. Leigh & Benjamin M. W. Roberts

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Borsley, S., Leigh, D.A. & Roberts, B.M.W. Chemical fuels for molecular machinery. Nat. Chem. 14, 728–738 (2022). https://doi.org/10.1038/s41557-022-00970-9

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