Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Trisubstituted triumph

Trisubstituted macrocyclic alkenes are prominent moieties in natural products, and although ring-closing metathesis reactions can be used to access such targets, the yields are typically suboptimal and the stereochemical outcome is unpredictable. Now, a methodology has been developed that tackles both of these challenges.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Macrocyclic ring-closing metathesis for the synthesis of E- and Z-trisubstituted macrocyclic alkenes.


  1. Driggers, E. M., Hale, S. P., Lee, J. & Terrett, N. K. Nat. Rev. Drug Discov. 7, 608–624 (2008).

    Article  CAS  Google Scholar 

  2. Marsault, E. & Peterson, M. L. J. Med. Chem. 54, 1961–2004 (2011).

    Article  CAS  Google Scholar 

  3. Hoveyda, A. H. & Zhugralin, A. R. Nature 450, 243–251 (2007).

    Article  CAS  Google Scholar 

  4. Mu, Y. et al. Nat. Chem. (2022).

  5. Xu, Z. et al. J. Am. Chem. Soc. 119, 10302–10316 (1997).

    Article  CAS  Google Scholar 

  6. Hanson, P. R. et al. J. Org. Chem. 76, 4358–4370 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Damian W. Young.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Young, D.W., Chamakuri, S. Trisubstituted triumph. Nat. Chem. 14, 595–597 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing