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Tungsten’s tandem transformation

Being able to run two reactions concurrently enables synthetic methods to be streamlined, but simultaneously controlling the selectivity of both reactions is an enormous challenge. Now, a directing group is used to reinvent a classic tandem reaction, activating specific sp3 C–H bonds with pinpoint accuracy.

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Fig. 1: Overview of isomerization/carbonylation tandem catalysis.


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Correspondence to Graham E. Dobereiner.

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Jenny, S.E., Dobereiner, G.E. Tungsten’s tandem transformation. Nat. Chem. 14, 594–595 (2022).

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