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Seeing flying molecular elephants more clearly

Extending mass spectrometry measurements of biomolecules into the megadalton regime is challenging due to the limited resolving power of currently used mass analysers. Now, using single ion-charge detection Orbitrap mass spectrometry, a mass accuracy of 0.001% has been demonstrated for protein particles larger than 9 MDa.

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Fig. 1: Orbitrap-based CDMS.


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Correspondence to Muhammad A. Zenaidee or Joseph A. Loo.

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Zenaidee, M.A., Loo, J.A. Seeing flying molecular elephants more clearly. Nat. Chem. 14, 482–483 (2022).

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