Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A hot take on glucose

Christine M. Le takes a look at 2-[18F]fluoro-2-deoxyglucose and explains how this radioactive sugar could help to save your life.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others


  1. Pacák, J., Točík, Z. & Černý, M. J. Chem. Soc. D 77 (1969).

  2. Ido, T. et al. J. Labelled Comp. Radiopharm. 14, 175–183 (1978).

    Article  CAS  Google Scholar 

  3. Fowler, J. S. & Ido, T. Semin. Nucl. Med. 32, 6–12 (2002).

    Article  Google Scholar 

  4. Hamacher, K., Coenen, H. H. & Stocklin, G. J. NucI. Med. 27, 235–238 (1986).

    CAS  Google Scholar 

  5. Jacobson, O., Kiesewetter, D. O. & Chen, X. Bioconjugate Chem. 26, 1–18 (2015).

    Article  CAS  Google Scholar 

  6. Le Bar, D. J. Fluor. Chem. 127, 1488–1493 (2006).

    Article  Google Scholar 

  7. Coenen, H. H. et al. Nucl. Med. Biol. 37, 727–740 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Christine M. Le.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Le, C.M. A hot take on glucose. Nat. Chem. 14, 476 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing