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ANTIBIOTIC RESISTANCE

A hydroxide lock for metallo-β-lactamases

Nature Chemistry volume 14, pages 6–8 (2022)Cite this article

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It is extremely difficult to design a broad-spectrum inhibitor for metallo-β-lactamases (MBLs) due to the diversity in the active site. Now, indole-2-carboxylates have been developed as broad-spectrum inhibitors for MBLs. These inhibitors take advantage of key elements of both MBL substrates and products and work by locking a hydroxide.

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Fig. 1: Strategies for MBL inhibitor design.

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Authors and Affiliations

  1. Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, P. R. China

    Hongyan Li & Hongzhe Sun

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  1. Hongyan Li
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  2. Hongzhe Sun
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Correspondence to Hongzhe Sun.

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The authors declare no competing interests.

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Li, H., Sun, H. A hydroxide lock for metallo-β-lactamases. Nat. Chem. 14, 6–8 (2022). https://doi.org/10.1038/s41557-021-00871-3

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