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Handling a protein with a nanopore machine

A protein–nanopore machine that can unfold, thread and degrade a protein has now been developed. Fabricated in a bottom-up fashion, the nanopore machine is assembled from three proteins and provides an important step towards deciphering the sequence of single proteins via nanopores.

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Fig. 1: Handling a single protein through a nanopore machine.


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Correspondence to Yi-Lun Ying.

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Ying, YL. Handling a protein with a nanopore machine. Nat. Chem. 13, 1160–1162 (2021).

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