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Signal transduction with a swing

The continuous monitoring of proteins is a current challenge in medical diagnostics. A new electrochemical approach aiming to address this has been described. The method uses antibodies as a recognition element to achieve the real-time measurement of proteins in saliva in the mouth.

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Fig. 1: Molecular pendulum signal transduction.


  1. Hippocrates. The Book of Prognostics (trans. Adams, F.) (William Wood & Company, 1886).

  2. Das, J. et al. Nat. Chem. (2021).

  3. Dunn, M. R., Jimenez, R. M. & Chaput, J. C. Nat. Rev. Chem. 1, 0076 (2017).

    Article  CAS  Google Scholar 

  4. Langer, A. et al. Nat. Commun. 4, 2099 (2013).

    Article  Google Scholar 

  5. Cash, K. J., Ricci, F. & Plaxco, K. W. J. Am. Chem. Soc. 131, 6955–6957 (2009).

    Article  CAS  Google Scholar 

  6. Malamud, D. Dent. Clin. North. Am. 55, 159–178 (2011).

    Article  Google Scholar 

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Correspondence to Kevin W. Plaxco.

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Cash, K.J., Plaxco, K.W. Signal transduction with a swing. Nat. Chem. 13, 392–393 (2021).

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