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DNA-ENCODED LIBRARIES

Expanding the effectiveness of screening

DNA-encoded libraries are a powerful tool to identify hit compounds for drug discovery. Now, two papers have reported new advances in this technology. One paper reports a method to screen for binders inside a living cell, and the other investigates the effects of stereo- and regiochemistry on ligand discovery.

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Fig. 1: Screening of DELs inside a living cell using cBTE.
Fig. 2: Investigation of the effect of stereo- and regiochemistry on ligand discovery.

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Correspondence to Minsoo Song or Gil Tae Hwang.

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Song, M., Hwang, G.T. Expanding the effectiveness of screening. Nat. Chem. 13, 515–517 (2021). https://doi.org/10.1038/s41557-021-00690-6

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