The therapeutic applications of DNAzymes are limited because of their low effectiveness in vivo. Now, a promising approach for constructing DNAzymes that show high gene-silencing efficiency in mammalian cells has been developed. This approach incorporates chemical modifications into an existing DNAzyme scaffold.
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Zhou, Y., Zhou, C. Designing in vivo active DNAzymes. Nat. Chem. 13, 299–301 (2021). https://doi.org/10.1038/s41557-021-00669-3
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DOI: https://doi.org/10.1038/s41557-021-00669-3
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