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SYNTHETIC METHODOLOGY

An asymmetric smile

Nature Chemistry volume 13, pages 304–305 (2021)Cite this article

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The formation of all-carbon quaternary centres is a challenging problem in organic chemistry, with far-reaching implications for functional molecule discovery. Now an inventive solution has been developed, using sulfinamides as traceless linkers for an asymmetric radical Truce–Smiles rearrangement.

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Fig. 1: The Truce–Smiles reaction for the creation of chiral arene molecules.

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  1. Twitter: @greaneygroup

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  1. Department of Chemistry, University of Manchester, Manchester, UK

    David M. Whalley & Michael F. Greaney

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  1. David M. Whalley
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  2. Michael F. Greaney
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Correspondence to Michael F. Greaney.

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The authors declare no competing interests.

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Whalley, D.M., Greaney, M.F. An asymmetric smile. Nat. Chem. 13, 304–305 (2021). https://doi.org/10.1038/s41557-021-00664-8

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