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CRYSTAL GROWTH

Symmetry in the making

After years of speculation on the origins of symmetry-making and -breaking during crystallization, time-resolved in situ scanning probe microscopy and all-atom molecular dynamics simulations have shown that the formation of olanzapine crystals largely occurs by the incorporation of centrosymmetric dimers into growth sites.

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Fig. 1: Inversion symmetry emerges as OZPN dimerizes in solution prior to crystallization.

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Correspondence to Susan M. Reutzel-Edens.

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Reutzel-Edens, S.M. Symmetry in the making. Nat. Chem. 12, 887–888 (2020). https://doi.org/10.1038/s41557-020-0547-8

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