Enzymes that methylate using S-adenosyl-l-methionine — nature’s methyliodide — are abundant and often promiscuous; however, a preference for alkylation over methylation has been neither observed in nature nor engineered. Now, carboxymethylation has been demonstrated using engineered methyltransferases.
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Struck, A.-W., Thompson, M. L., Wong, L. S. & Micklefield, J. ChemBioChem 13, 2642–2655 (2012).
Schönherr, H. & Cernak, T. Angew. Chem. Int. Ed. 52, 12256–12267 (2013).
Huber, T. D., Johnson, B. R., Zhang, J. & Thorson, J. S. Curr. Opin. Biotechnol. 42, 189–197 (2016).
Herbert, A. J. et al. Angew. Chem. Int. Ed. https://doi.org/10.1002/anie.202004963 (2020).
Kim, J. et al. Nature 498, 123–126 (2013).
Ting, C. P. et al. Science 365, 280–284 (2019).
Fontecave, M., Atta, M. & Mulliez, E. Trends Biochem. Sci. 29, 243–249 (2004).
Cornelissen, N. V., Michailidou, F., Muttach, F., Rau, K. & Rentmeister, A. Chem. Commun. https://doi.org/10.1039/C9CC07807J (2020).
The authors declare no competing interests.
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Andexer, J.N., Rentmeister, A. Challenging nature’s preference for methylation. Nat. Chem. 12, 791–792 (2020). https://doi.org/10.1038/s41557-020-0533-1
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