Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Harder, better, faster

The gap between fundamental academic research and the applied industrial research that is necessary to ensure real-world applications can be bridged by engaging in well-defined collaborative academia–industry projects and fostering better communication between the scientists involved in them.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: The drug-development process.
Fig. 2: When academia and industry collide.
Fig. 3: Adoption of photoredox catalysis at Merck.

References

  1. 1.

    Landhuis, E. Nature 577, 585–587 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Brown, D. G. & Boström, J. J. Med. Chem. 59, 4443–4458 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Ruiz-Castillo, P. & Buchwald, S. L. Chem. Rev. 116, 12564–12649 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Dorel, R., Grugel, C. P. & Haydl, A. M. Angew. Chem. Int. Ed. 58, 17118–17129 (2019).

    CAS  Article  Google Scholar 

  5. 5.

    Nuhant, P. et al. Angew. Chem. Int. Ed. 56, 15309–15313 (2017).

    CAS  Article  Google Scholar 

  6. 6.

    Oderinde, M. S., Frenette, M., Robbins, D. W., Aquila, B. & Johannes, J. W. J. Am. Chem. Soc. 138, 1760–1763 (2016).

    CAS  Article  Google Scholar 

  7. 7.

    Bloom, S. et al. Nat. Chem. 10, 205–211 (2018).

    CAS  Article  Google Scholar 

  8. 8.

    Loh, Y. Y. et al. Science 358, 1182–1187 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Perry, I. B. et al. Nature 560, 70–75 (2018).

    CAS  Article  Google Scholar 

  10. 10.

    Corcoran, E. B. et al. Science 353, 279–283 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Douglas, J. J., Cole, K. P. & Stephenson, C. R. J. J. Org. Chem. 79, 11631–11643 (2014).

    CAS  Article  Google Scholar 

  12. 12.

    McManus, J. B., Onuska, N. P. R., Jeffreys, M. S., Goodwin, N. C. & Nicewicz, D. A. Org. Lett. 22, 679–683 (2020).

    CAS  Article  Google Scholar 

  13. 13.

    Yayla, H. G. et al. Chem. Sci. 7, 2066–2073 (2016).

    CAS  Article  Google Scholar 

  14. 14.

    Miller, D. C. et al. J. Am. Chem. Soc. 141, 16590–16594 (2019).

    CAS  Article  Google Scholar 

  15. 15.

    Hell, S. M. et al. J. Am. Chem. Soc. 142, 720–725 (2020).

    CAS  Article  Google Scholar 

  16. 16.

    Nicastri, M. C., Lehnherr, D., Lam, Y.-h., DiRocco, D. A. & Rovis, T. J. Am. Chem. Soc. 142, 987–998 (2020).

  17. 17.

    Nielsen, M. K. et al. Angew. Chem. Int. Ed. 56, 7191–7194 (2017).

    CAS  Article  Google Scholar 

  18. 18.

    Le, C. et al. ACS Cent. Sci. 3, 647–653 (2017).

    CAS  Article  Google Scholar 

  19. 19.

    Bonfield, H. E. et al. ChemPhotoChem 4, 45–51 (2020).

    CAS  Article  Google Scholar 

  20. 20.

    Halperin, S. D. et al. Org. Lett. 17, 5200–5203 (2015).

    CAS  Article  Google Scholar 

  21. 21.

    Harper, K. C., Moschetta, E. G., Bordawekar, S. V. & Wittenberger, S. J. ACS Cent. Sci. 5, 109–115 (2019).

    CAS  Article  Google Scholar 

  22. 22.

    Nagib, D. A. & MacMillan, D. W. C. Nature 480, 224–228 (2011).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

The authors thank B. Burkett (@ChemScrapes) for contributing Fig. 2.

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Danielle Schultz or Louis-Charles Campeau.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Schultz, D., Campeau, LC. Harder, better, faster. Nat. Chem. 12, 661–664 (2020). https://doi.org/10.1038/s41557-020-0510-8

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing