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SYNTHETIC METHODOLOGY

Decorating and diversifying drugs

The direct conversion of lead compounds into potentially more potent derivatives, through selective functionalization, could help to speed up the discovery of drug candidates. Now, a method has been reported that enables the late-stage C–H methylation of complex drug-like molecules, using a sustainable cobalt-based catalyst.

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Fig. 1: Late-stage methylation for medicinal chemistry.

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Correspondence to Joanna Wencel-Delord.

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Wencel-Delord, J. Decorating and diversifying drugs. Nat. Chem. 12, 505–506 (2020). https://doi.org/10.1038/s41557-020-0479-3

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Further reading

  • C–H activation

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    Nature Reviews Methods Primers (2021)

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