The widespread application of quinone methides — reactive intermediates in a variety of reactions — is limited by their tedious synthesis. Now, hypoiodite catalysis allows the efficient generation and use of these species in a plethora of tandem processes for the functionalization and synthesis of biologically active compounds.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Willis, N. J. & Bray, C. D. Chem. Eur. J. 18, 9160–9173 (2012).
Bai, W.-J. et al. Acc. Chem. Res. 47, 3655–3664 (2014).
Jaworski, A. A. & Scheidt, K. A. J. Org. Chem. 81, 10145–10153 (2016).
Uyanik, M., Nishioka, K., Kondo, R. & Ishihara, K. Nat. Chem. https://doi.org/10.1038/s41557-020-0433-4 (2020).
Uyanik, M., Okamoto, H., Yasui, T. & Ishihara, K. Science 328, 1376–1379 (2010).
Uyanik, M., Nishioka, K. & Ishihara, K. Heterocycles 95, 1132–1147 (2017).
Minard, A., Liano, D., Wang, X. & Di Antonio, M. Bioorg. Med. Chem. 27, 2298–2305 (2019).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nachtsheim, B.J. Mild map to quinone methides. Nat. Chem. 12, 326–328 (2020). https://doi.org/10.1038/s41557-020-0443-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-020-0443-2