Metal-catalysed hydroformylations efficiently convert feedstock alkenes into aldehydes, though typically relatively simple ones. Now, the palladium-catalysed fragmentation of acid chlorides followed by reassembly with alkynes and silanes has been shown to form valuable, highly substituted α,β-unsaturated aldehydes.
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The authors declare no competing interests.
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Zgheib, J., Arndtsen, B.A. Fragmentation and reassembly. Nat. Chem. 13, 110–111 (2021). https://doi.org/10.1038/s41557-020-00631-9