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Fragmentation and reassembly

Metal-catalysed hydroformylations efficiently convert feedstock alkenes into aldehydes, though typically relatively simple ones. Now, the palladium-catalysed fragmentation of acid chlorides followed by reassembly with alkynes and silanes has been shown to form valuable, highly substituted α,β-unsaturated aldehydes.

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Fig. 1: A versatile, palladium-catalysed carboformylation reaction to prepare highly substituted α,β-unsaturated aldehydes.


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Correspondence to Bruce A. Arndtsen.

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Zgheib, J., Arndtsen, B.A. Fragmentation and reassembly. Nat. Chem. 13, 110–111 (2021).

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