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Taking stock of stacking

The manner in which adjacent sheets stack in layered covalent organic frameworks largely influences their material properties, including chemical stability, crystallinity and porosity. The layer stacking of a COF has now been probed locally, showing disorder that is not detected through long-range characterization.

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Fig. 1: Visualization of different COF stacking motifs.
Fig. 2: Reaction scheme for the imine-linked COF synthesis.


  1. Côté, A. P. et al. Science 310, 1166–1170 (2005).

    Article  Google Scholar 

  2. El‐Kaderi, H. M. et al. Science 316, 268–272 (2007).

    Article  Google Scholar 

  3. Lohse, M. S. & Bein, T. Adv. Funct. Mater. 28, 1705553 (2018).

    Google Scholar 

  4. Lukose, B. et al. Chem. Eur. J. 17, 2388–2390 (2011).

    Article  CAS  Google Scholar 

  5. Haase, F. et al. Mater. Chem. Front. 1, 1354–1361 (2017).

    Article  CAS  Google Scholar 

  6. Pütz, A. M. et al. Chem. Sci. (2020).

  7. Hu, J. et al. ACS Appl. Nano Mater. 3, 6239–6269 (2020).

    Article  CAS  Google Scholar 

  8. Martínez-Abadía, M. & Mateo-Alonso, A. Adv. Mater. 32, 2002366 (2020).

    Article  Google Scholar 

Download references

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Correspondence to Dana D. Medina.

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Mähringer, A., Medina, D.D. Taking stock of stacking. Nat. Chem. 12, 985–987 (2020).

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