It’s generally assumed that primitive forms of cellular life arose from nucleic acids and peptides compartmentalized within vesicles — all underpinned by a non-enzymatic protometabolism. Three studies now provide new insights into the ancient chemistry that may have supported early biology.
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Proteome-wide 3D structure prediction provides insights into the ancestral metabolism of ancient archaea and bacteria
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Fahrenbach, A.C., Tran, Q.P. Prebiotic metabolism gets a boost. Nat. Chem. 12, 982–985 (2020). https://doi.org/10.1038/s41557-020-00567-0