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Decorating proteins with LACE

Labelling proteins at internal sites holds promise for generating novel protein conjugates in a programmable fashion. Now, a chemoenzymatic approach, dubbed LACE, enables the site-specific modification of recombinant proteins that contain a short genetically encoded tag.

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Fig. 1: Labelling proteins at internal sites via chemoenzymatic approaches.


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Correspondence to Kathrin Lang.

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Fottner, M., Lang, K. Decorating proteins with LACE. Nat. Chem. 12, 980–982 (2020).

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