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Identifying an iodinase


Flavin-dependent halogenases catalyse the regioselective formation of carbon–chlorine and carbon–bromine bonds using oxygen and inorganic halide salts. Now, genome mining has led to the discovery of a previously unknown viral halogenase that catalyses the iodination of arenes, thereby providing a rare biocatalytic tool for the formation of carbon–iodine bonds.

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Fig. 1: Mining of novel halogenases using a bioinformatics-based approach.


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Correspondence to Nicholas J. Turner.

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Schnepel, C., Turner, N.J. Identifying an iodinase. Nat. Chem. 11, 1076–1078 (2019).

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