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CHEMICAL BIOLOGY

Diverse engineering

Methods for generating molecular diversity provide a route to screen a wider section of chemical space, to discover compounds with useful biological properties. Now, a complexity-to-diversity strategy has enabled the discovery of a multi-cyclic structure from a complex natural product that induces ferroptotic cell death in cancer cells.

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Fig. 1: Complexity-to-diversity strategy reveals a novel thioredoxin inhibitor and inducer of ferroptosis.

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Correspondence to Raphaël Rodriguez.

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Cañeque, T., Rodriguez, R. Diverse engineering. Nat. Chem. 11, 499–500 (2019). https://doi.org/10.1038/s41557-019-0269-y

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