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Diverse engineering

Methods for generating molecular diversity provide a route to screen a wider section of chemical space, to discover compounds with useful biological properties. Now, a complexity-to-diversity strategy has enabled the discovery of a multi-cyclic structure from a complex natural product that induces ferroptotic cell death in cancer cells.

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Fig. 1: Complexity-to-diversity strategy reveals a novel thioredoxin inhibitor and inducer of ferroptosis.


  1. 1.

    Schreiber, S. L. Science 287, 1964–1969 (2000).

    CAS  Article  Google Scholar 

  2. 2.

    Kuruvilla, F. G., Shamji, A. F., Sternson, S. M., Hergenrother, P. J. & Schreiber, S. L. Nature 416, 653–657 (2002).

    CAS  Article  Google Scholar 

  3. 3.

    Kumar, K. & Waldmann, H. Angew. Chem. Int. Ed. 48, 3224–3242 (2009).

    CAS  Article  Google Scholar 

  4. 4.

    Llabani, E. et al. Nat. Chem. (2019).

  5. 5.

    Huigens, R. W. III et al. Nat. Chem. 5, 195–202 (2013).

    CAS  Article  Google Scholar 

  6. 6.

    Dixon, S. J. et al. Cell 149, 1060–1072 (2012).

    CAS  Article  Google Scholar 

  7. 7.

    Mai, T. T. et al. Nat. Chem. 9, 1025–1033 (2017).

    CAS  Article  Google Scholar 

  8. 8.

    Viswanathan, V. S. et al. Nature 547, 453–457 (2017).

    CAS  Article  Google Scholar 

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Correspondence to Raphaël Rodriguez.

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Cañeque, T., Rodriguez, R. Diverse engineering. Nat. Chem. 11, 499–500 (2019).

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