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CHEMICAL BIOLOGY

Diverse engineering

Nature Chemistry (2019) | Download Citation

Methods for generating molecular diversity provide a route to screen a wider section of chemical space, to discover compounds with useful biological properties. Now, a complexity-to-diversity strategy has enabled the discovery of a multi-cyclic structure from a complex natural product that induces ferroptotic cell death in cancer cells.

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Author information

Affiliations

  1. Institut Curie, Paris, France

    • Tatiana Cañeque
    •  & Raphaël Rodriguez
  2. CNRS UMR 3666, Paris, France

    • Tatiana Cañeque
    •  & Raphaël Rodriguez
  3. INSERM U1143 , Paris, France

    • Tatiana Cañeque
    •  & Raphaël Rodriguez
  4. PSL University Paris, Paris, France

    • Tatiana Cañeque
    •  & Raphaël Rodriguez

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Corresponding author

Correspondence to Raphaël Rodriguez.

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DOI

https://doi.org/10.1038/s41557-019-0269-y

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