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Nitrogen gets radical

The direct formation of C–N bonds onto arenes provides a simple route to synthesize a variety of important products. Now, formation of a highly polarized, aminium radical cation enables direct C–H amination, allowing the coupling of an exceptionally broad range of alkyl amines and arenes.

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Fig. 1: The development of a broadly applicable, photocatalytic method for intermolecular C–H amination of a wide range of arenes with alkyl amines.


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Correspondence to David Nagib.

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Nagib, D. Nitrogen gets radical. Nat. Chem. 11, 396–398 (2019).

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