The formation of carbon–nitrogen bonds for the preparation of aromatic amines is among the top five reactions carried out globally for the production of high-value materials, ranging from from bulk chemicals to pharmaceuticals and polymers. As a result of this ubiquity and diversity, methods for their preparation impact the full spectrum of chemical syntheses in academia and industry. In general, these molecules are assembled through the stepwise introduction of a reactivity handle in place of an aromatic C–H bond (that is, a nitro group, halogen or boronic acid) and a subsequent functionalization or cross-coupling. Here we show that aromatic amines can be constructed by direct reaction of arenes and alkyl amines using photocatalysis, without the need for pre-functionalization. The process enables the easy preparation of advanced building blocks, tolerates a broad range of functionalities, and multigram scale can be achieved via a batch-to-flow protocol. The merit of this strategy as a late-stage functionalization platform has been demonstrated by the modification of several drugs, agrochemicals, peptides, chiral catalysts, polymers and organometallic complexes.
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All data supporting the findings of this study are available within the Supplementary Information. These include reaction procedures, products characterization, the batch-to-flow experiment procedure, the microscale parallel screening procedure, cyclic voltammograms and UV–vis, density functional theory and NMR spectra.
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The authors thank M. Simonetti and F. Juliá-Hernandez for useful discussions. D.L. thanks EPSRC for a Fellowship (EP/P004997/1) and the European Research Council for a research grant (758427). A.R. thanks the Marie Curie Actions for a Fellowship (703238).
Synthetic procedures; products characterization; electrochemical, UV–vis, emission quenching and DFT studies; NMR spectra.