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Pulling together to improve stability

Maleimide–thiol adducts are popular in both bioconjugation and materials chemistry, however, they are unstable under physiological conditions. Now, a mechanochemical approach uses pulling forces to stabilize maleimide–thiol adducts and improve the stability of polymer–protein conjugates.

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Fig. 1: Mechanochemical acceleration of hydrolysis of thiol-maleimide adducts.


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Correspondence to Phillip B. Messersmith.

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Higginson, C.J., Messersmith, P.B. Pulling together to improve stability. Nat. Chem. 11, 295–296 (2019).

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