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NATURAL PRODUCT SYNTHESIS

Simple start for complex products

Natural products often provide lead scaffolds for the development of therapeutics, but complexity of their synthesis can limit the discovery of improved analogues. Pharmacophore-directed retrosynthesis aims to accelerate the building of a structure–activity relationship profile of a natural product, aiming to identifying a simplified lead.

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Fig. 1: Pharmacophore-directed retrosynthesis (PDR).

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Correspondence to Gary A. Sulikowski.

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Hudlicky, J.R., Sulikowski, G.A. Simple start for complex products. Nat. Chem. 11, 297–298 (2019). https://doi.org/10.1038/s41557-019-0241-x

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