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Simple start for complex products

Natural products often provide lead scaffolds for the development of therapeutics, but complexity of their synthesis can limit the discovery of improved analogues. Pharmacophore-directed retrosynthesis aims to accelerate the building of a structure–activity relationship profile of a natural product, aiming to identifying a simplified lead.

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Fig. 1: Pharmacophore-directed retrosynthesis (PDR).


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Correspondence to Gary A. Sulikowski.

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Hudlicky, J.R., Sulikowski, G.A. Simple start for complex products. Nat. Chem. 11, 297–298 (2019).

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