Natural products often provide lead scaffolds for the development of therapeutics, but complexity of their synthesis can limit the discovery of improved analogues. Pharmacophore-directed retrosynthesis aims to accelerate the building of a structure–activity relationship profile of a natural product, aiming to identifying a simplified lead.
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Hudlicky, J.R., Sulikowski, G.A. Simple start for complex products. Nat. Chem. 11, 297–298 (2019). https://doi.org/10.1038/s41557-019-0241-x
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DOI: https://doi.org/10.1038/s41557-019-0241-x
