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OLIGOSACCHARIDE SYNTHESIS

Robots command enzymes

Enzymatic approaches to synthesize oligosaccharides offer an alternative to chemical syntheses for the production of homogeneous glycans; however, enzyme-based routes typically require lengthy processes. Now, the design of a water-soluble affinity tag has enabled the automation of multistep enzymatic syntheses of mammalian oligosaccharides.

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Correspondence to Nicola L. B. Pohl.

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Fig. 1: The water-soluble affinity tag enables the automation of multiple enzymatic reactions.