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STRUCTURE DETERMINATION

Big insights from tiny crystals

Most compounds form crystals so small that scientists cannot experimentally determine their atomic structures using X-ray crystallography. Microcrystal electron diffraction now provides a unique solution for this challenge.

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Fig. 1: Setup showing how electron diffraction can be used to solve the atomic structure of microcrystalline powder components.

References

  1. Gruene, T. et al. Angew. Chem. Int. Ed. 57, 16313–16317 (2018).

    Article  CAS  Google Scholar 

  2. Jones, C. G. et al. ACS Cent. Sci. 4, 1587–1592 (2018).

    Article  CAS  Google Scholar 

  3. Wagner, T. High through-put chemical structure determination. In SHELX Symposium (University of Göttingen, 2011).

  4. Glaeser, R. M. & Taylor, K. A. J. Microsc. 112, 127–138 (1978).

    Article  CAS  Google Scholar 

  5. Longley, W. J. Mol. Biol. 30, 323–327 (1967).

    Article  CAS  Google Scholar 

  6. Kolb, U., Gorelik, T., Kübel, C., Otten, M. T. & Hubert, D. Ultramicroscopy 107, 507–513 (2007).

    Article  CAS  Google Scholar 

  7. Wang, Y. et al. Chem. Commun. 53, 7018–7021 (2017).

    Article  CAS  Google Scholar 

  8. Shi, D., Nannenga, B. L., Iadanza, M. G. & Gonen, T. eLife 2, e01345 (2013).

    Article  Google Scholar 

Download references

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Correspondence to Stefan Raunser.

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Sitsel, O., Raunser, S. Big insights from tiny crystals. Nature Chem 11, 106–108 (2019). https://doi.org/10.1038/s41557-019-0211-3

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