Transport at the molecular scale is a prerequisite for the development of future molecular factories. Here, we have designed oligoanionic molecular sliders on polycationic tracks that exploit Brownian motion and diffusive binding to transport cargo without using a chemical fuel. The presence of the polymer tracks increases the rate of bimolecular reactions between modified sliders by over two orders of magnitude. Molecular dynamics simulations showed that the sliders not only diffuse, but also jump and hop surprisingly efficiently along polymer tracks. Inspired by acetyl-coenzyme A transporting and delivering acetyl groups in many essential biochemical processes, we developed a new and unconventional type of catalytic transport involving sliders (including coenzyme A) picking up, transporting and selectively delivering molecular cargo. Furthermore, we show that the concept of diffusive binding can also be utilized for the spatially controlled transport of chemical groups across gels. This work represents a new concept for designing functional nanosystems based on random Brownian motion.
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The authors declare that all the data generated and analysed during this study are included within this Article and its Supplementary Information. The software and codes used to perform simulation and analysis are cited in the Article. The data sets are available from authors Y.H. and P.K. on reasonable request.
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This work was supported by the Netherlands Organization for Scientific Research (NWO) TOPPUNT grant 718.014.001 (to W.T.S.H.), the Ministry of Education, Culture and Science (Gravity programme, 024.001.035, to W.T.S.H.), an NSF DMR-1506886 grant (to P.K.) and by start-up funding from the University of Texas at El Paso (to L.V.). H.Z. is a recipient of a Radboud Excellence Fellowship.
The authors declare no competing interests.
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Zheng, L., Zhao, H., Han, Y. et al. Catalytic transport of molecular cargo using diffusive binding along a polymer track. Nat. Chem. 11, 359–366 (2019). https://doi.org/10.1038/s41557-018-0204-7
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